Solvation Layer of Antifreeze Proteins Analyzed with a Markov State Model
نویسندگان
چکیده
منابع مشابه
Speech recognition with a generative factor analyzed hidden Markov model
We present a generative factor analyzed hidden Markov model (GFA-HMM) for automatic speech recognition. In a traditional HMM, the observation vectors are represented by mixture of Gaussians (MoG) that are dependent on discrete-valued hidden state sequence. The GFA-HMM introduces a hierarchy of continuousvalued latent representation of observation vectors, where latent vectors in one level are a...
متن کاملAntifreeze proteins
The antifreeze protein (AFP) activity is explained using two models. The first model is using ice binding and the second is using antiice structuralization of water molecules. The description of AFP function using anti-ice structuralization of water molecules is less explored. Therefore, it is of interest to explain AFP function using this model. Protein folding is often described using models ...
متن کاملDNA looping kinetics analyzed using diffusive hidden Markov model.
Tethered particle experiments use light microscopy to measure the position of a micrometer-sized bead tethered to a microscope slide via an approximately micrometer-length polymer, to infer the behavior of the invisible polymer. Currently, this method is used to measure rate constants of DNA loop formation and breakdown mediated by repressor protein that binds to the DNA. We report a new techni...
متن کاملEvolution of the diverse antifreeze proteins.
Different types of ice-growth-inhibiting antifreeze proteins, first recognized in fish, have now been isolated from insects and plants, and the list continues to expand. Their structures are amazingly diverse; how they attain the same function are subjects of intense research. Evolutionary precursors of several members have been identified - divergent proteins of apparently unrelated function. ...
متن کاملOligomeric state of membrane transport proteins analyzed with blue native electrophoresis and analytical ultracentrifugation.
Blue native electrophoresis is used widely for the analysis of non-dissociated protein complexes with respect to composition, oligomeric state and molecular mass. However, the effects of detergent or dye binding on the mass and stability of the integral membrane proteins have not been studied. By comparison with analytical ultracentrifugation, we have evaluated whether the oligomeric state of m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2018
ISSN: 1520-6106,1520-5207
DOI: 10.1021/acs.jpcb.8b04491